Microwave assisted synthesis and pharmacological evaluation of few substituted 4-thiazolidinone derivatives

Authors : Dinesh D. Rishipathak, Poonam S.Wajpeyi, Sonal P. Tathe, Pavan B. Udavant

DOI : 10.18231/j.ijpca.2019.008

Volume : 6

Issue : 2

Year : 2019

Page No : 44-48

In present investigation the synthesis of few 2-(substituted phenyl-3-(5-substituted phenyl-4H-1, 2, 4-triazole-3-yl)-thiazolidine-4-ones and 3-(5-(4-substituted phenyl)-1, 3, 4-thiadiazole-2-yl)-2-phenylthiazolidine-4-ones is reported with the aim of achieving enhanced anticonvulsant effect. Two schemes were designed viz. first scheme for clubbed triazole-thiazolidinone derivatives and second scheme for clubbed thiadiazole-thiazolidinone derivatives. The compounds were characterized on the basis of IR, ¹H-NMR and Mass analyses. Acute toxicity study was done to determine the LD₅₀ of the compounds. Some of the compounds were evaluated for their anticonvulsant activity using PTZ induced convulsions method. The compounds DCThizd-N and NMThizd-N showed highest percentage of protection (80%) at the dose of 30mg/kg among the evaluated compounds compared to control.

Keywords: 4-Thiazolidinone, Triazole, Thiadiazole, Anticonvulsant activity.

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