Authors : Sindhu S, V Y Srinivas
DOI : 10.18231/j.ijca.2020.024
Volume : 7
Issue : 1
Year : 2020
Page No : 136-141
Introduction and Objective: Direct laryngoscopy and endotracheal intubation evokes autonomic
disturbances in the form of tachycardia, raise in blood pressure, intracranial, and intraocular pressure.
Thus the present study was undertaken to evaluate the efficacy of injection Labetalol 0.25mg/kg body
weight in the attenuation of sympathoadrenal response to direct laryngoscopy and endotracheal intubation.
Materials and Methods: The study was conducted on 60 participants belonging to ASA grade 1 or 2 aged
between 18 – 55 yrs undergoing elective surgeries under general anaesthesia. The study population was
randomly divided into 2 groups with 30 subjects in each group.
Group LAB (Labetalol group) – received 0.25mg/kg body weight diluted upto 10ml with normal saline
intravenously, over 10minutes using a syringe pump, given 10minutes before induction.
Group CR (Control) received 10ml of normal saline intravenously.
The study drug was administered over 10 minutes using syringe pump followed by induction with
inj Thiopentone 5mg/kg body weight and inj vecuronium 0.1mg/kg body weight three minutes prior
to laryngoscopy and intubation. HR(Heart rate), Systolic arterial pressure, diastolic arterial pressure,
MAP(mean arterial pressure) were recorded at basal, 2 minutes, 5 minutes, 8 minutes after study drug
infusion, before induction, after induction, 1st , 2nd , 3rd , 5th, 10th, 15th minute after laryngoscopy and
intubation.
Results: The result showed statistically significant (p<0> Pressure, Diastolic arterial pressure and Mean arterial pressure in Group LAB compared to Group CR
at all the time intervals.
Interpretation and Conclusion: In the present study, it was found that inj Labetalol 0.25mg/kg body
weight had effectively attenuated the sympathoadrenal response to laryngoscopy and intubation.
Keywords: Labetalol, Laryngoscopy, Endotracheal intubation, Attenuation; Sympathoadrenal response.