Authors : Khandu Hotkar, Vandana Jain, Nikhil Deshpande, Mukund Sarje, D S Chature
DOI : 10.18231/j.ijcbr.2020.021
Volume : 7
Issue : 1
Year : 2020
Page No : 102-110
High doses of radiation therapy are used to destroy cancer cells, these high doses of radiations also damage
healthy cells and tissues near the treatment area or whole body. At present, major advances of radiation
therapy have made it more precise, leading to fewer side effects. The side effects often start during
second week of radiation treatment So it is necessary to minimize these side effects with natural available
medication. Previous studies shown that, 2- deoxy D- glucose, an analogue of glucose and glycolytic
inhibitor, enhances radiation induced damage, selectively in tumour cells while protecting normal cells
suggest that 2- deoxy D- glucose can be used as a differential radio modifier to improve the efficacy of
radiotherapy and also it is shown that antioxidant medicinal plants like vitis Vinifera, camellia Sinensis,
and zingiber officinale have shown protective effect against radiation induced damage in previous studies.
So in the present study, we have selected these antioxidant medicinal plant extracts combines with 2- deoxy
D- glucose as a treatment, before and after radiation therapy and measured the levels of nitric oxide, lipid
peroxidation and antioxidant enzymes like superoxide dismutase, catalase and glutathione peroxidase in
tissues like blood, liver, kidney and brain tissues of mice after completion of study. In the present study, it
is found that the highest effect is found in a group of animals which are on combination of normal diet and
feeding of deoxy – D glucose with grape seed extract, green tea extract and ginger extract in proportion of
1:1:1, in this group of animal’s radiation induced micronucleus formation, formation of metamyelocytes
and dysplastic myeloid series cells formation is also found significantly decreased.
Keywords: NO- Nitric oxide, TBARS- Thiobarbituric acid Reactive, Substances, SOD- Super oxide dismutase CATCatalase & GPx- Glutathione peroxidase