Authors : Prashanth Kumar B G, Soumya Goud, H L Vishwanath, Muralidhara Krishna C S
DOI : 10.18231/j.ijcbr.2019.110
Volume : 6
Issue : 4
Year : 2019
Page No : 526-529
Introduction: Hyaluronic Acid (HA) is produced by the endothelial smooth muscle cells and adventitial
fibroblasts of the arterial wall. In conditions of hyperglycemia, there is an accumulation of HA in blood
vessels and can contribute to the diabetic micro- and macrovascular complications. The current study aims
to determine the association of serum Hyaluronic Acid levels in Type 2 diabetes mellitus with diabetic
nephropathy and its correlation with diabetic indices and renal function test parameters.
Materials and Methods: 60 male subjects,30 cases of Type 2 Diabetes Mellitus patients with diabetic
nephropathy and 30 non-diabetic healthy subjects as controls. Fasting venous blood samples were collected
from cases and controls and analyzed for serum HA by ELISA and HBA1C, FBS, PPBS, urea, and
creatinine by Beckmann Coulter Au 480 automated analyser.24 hours urine was collected and analyzed
for urinary microalbumin by an immunoturbidimetric method. Statistical analysis was done with SPSS
package and p-value < 0>
Results: Serum HA levels were significantly higher in diabetic patients with nephropathy (756 ng/ml)
when compared to the normal control groups (255 ng/ml). Serum HA also showed a significant positive
correlation with FBS, PPBS, HbA1C, urea, creatinine and urine microalbumin.
Conclusion: Highly elevated serum Hyaluronic Acid levels and its positive correlation with diabetic indices
and renal function test parameters in Type 2 Diabetes Mellitus patients with diabetic nephropathy suggests
its association with poor blood glucose control and may possibly predict the development of diabetesrelated
vascular complications in Type 2 diabetics without any complications.
Keywords: Type 2 Diabetes Mellitus, Hyaluronic acid, Glycocalyx.