Authors : Nidhi Goel, Mohanvir Kaur, Manjit Singh Bal
DOI : 10.18231/j.achr.2020.011
Volume : 5
Issue : 1
Year : 2020
Page No : 47-57
Introduction: Lymphoma constituting 55.6% of hematological malignancy, its prognosis depends on the
correct diagnosis and stage of the disease, which is established after examination of peripheral blood film
(PBF), bone marrow aspiration (BMA) and bone marrow biopsy (BMB) along with other parameters.
Objective: The objective is to find out the percentage and pattern of bone marrow involvement, along with
peripheral blood changes in lymphoma.
Material and Methods: PBF, BMA and BMB findings studied in 60 lymphoma patients during a period
of 3 years. The PBF and aspiration smears stained with Leishmann’s stain, while the trephine biopsy
processed and stained with Haematoxylin and eosin (H & E) stain and Reticulin stain. The results were
scrutinized, compared and evaluated.
Results: The male to female ratio was 1.4:1, including 53(88.3%) cases of NHL and 7(11.7%) cases
of HL. Most common age group involved in NHL was 51-60 years and in HL was 31-40 years. 19/60
(31.7%) cases showed leucocytic lymphocytosis on PBF examination. Percentage lymphocytes in marrow
differential count was increased in 16(26.7%) cases and were reported with bone marrow involvement
on BMA and BMB and 1 case having borderline percentage lymphocyte count on BMA was reported as
bone marrow involved case, only after examining the BMB. The diffuse pattern of involvement was most
common in 7(41.2%), followed by paratrabecular pattern in 6(35.3%) cases.
Conclusion: Thus to conclude bone marrow examination give valuable information in lymphoma, about
disease burden, percentage of involvement, pattern of involvement and baseline involvement prior to
therapy.
Keywords: Lymphoma, Bone marrow aspiration, Bone marrow biopsy, Bone marrow involvement.