Evaluation of serum protein electrophoresis in patients with renal disorders

Authors : Shiv Sharma, Divya Soin, Harvinder Singh, Khushdeep Singh

DOI : 10.18231/j.ijcbr.2022.058

Volume : 9

Issue : 4

Year : 2022

Page No : 295-300

Introduction: One of the cardinal findings of the renal disease is proteinuria, which appears in the early phase of kidney disease and is very important in diagnosis, prognosis and decision-making in treatment process and results of treatment. Besides this abnormal protein fractions are commonly observed in renal disorder. Serum will be collected for protein electrophoresis and Quantization of each fraction was done. So the present study is designed to find the role of serum protein electrophoresis in renal disorder patients.
The aim of the present study was to study protein electrophoresis pattern in various renal disorders.
Materials and Methods: The present study was a hospital-based observational study. The study was conducted over a period of 1 year on 50 patients with renal disorder of either sex visiting the OPD/IPD of Medicine department of Guru Gobind Singh Medical College and Hospital Faridkot. SDS Page electrophoresis was done to evaluate serum proteins in the patients with renal disorders.
Result: The results of the study showed the comparison of protein content in patients of NS and ESRD at p<0 Albumin(t=3.86), Globulin(t=6.18), t=-2.76)>0.05). The Comparison of protein content in patients of NS and CKD at p<0 Albumin(t=5.42), Globulin(t=3.38)>0.05).
Conclusion: The present study concluded that serum protein fractions are altered in various renal disorders. Protein electrophoresis should be used in addition to other renal markers for better monitoring of the disease progression.

Keywords: Chronic kidney disease (CKD), End stage renal disorder (ESRD), Nephrotic syndrome (NS), Polyacrylamide gel electrophoresis (PAGE), Sodium dodecyl sulphate (SDS).

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