Melasma mystery: Oral tranexamic acid

Authors : Uday Kr Udayan, Pankaj Kr Tiwary, Ramawatar Singh

DOI : 10.18231/j.ijced.2020.051

Volume : 6

Issue : 3

Year : 2020

Page No : 254-256

Melasma is acquired localized hyper pigmentation of skin characterized by presence of asymptomatic light to dark brown colored macules on malar area, nose, forhead and sometimes chin. Tranexamic acid has been known for its antifibrinolytic effect through the reversible blockade of lysine binding sites on plasminogen molecules and Its usage in the treatment of melasma was accidentally discovered in 1979. Patients were randomly divided into 2 groups, each consisting 70 patients. Group A patients were given oral tranexamic acid 250 mg BD along with SPF 40 sunscreen at daytime and hydroquinone 4% at night. Group B patients
were given only topical treatment same as that of group A. Among group A patients decrement in mean MASI score from baseline was significant at both 12th (9.242.8) and 16th week (8.76 2.3) but not at 8th week (13.41.7), p value was <0> A. Tranexamic acid seems to be potential new medication as in various studies it has been shown to achieve melasma clearance.

Keywords: Trenexamic acid, Melasma, Pigmentation.

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