Status of lipid peroxidation and antioxidation in maxillary and vocal cord carcinoma
Introduction: Present study was conducted to investigate the oxidative, stress by measuring the lipid peroxidation marker Malondialdehyde (MDA) in maxillary cancer and vocal cord cancer. And, to study the role of non-enzymatic antioxidants like ascorbic acid (vitamin C) and tocopherols (vitamin E) in maxillary cancer and vocal cord cancer.
Materials and Methods: Total 100 patients were selected.
Inclusion Criteria: Study included Maxillary and Vocal cord patient.
Exclusion Criteria: The exclusion criteria were male factor chronic disease like chronic heart disease (CHD), hypertension, ischemic heart disease, diabetes mellitus (DM), chronic obstructive pulmonary disease (COPD), other major systemic illness in different age group. MDA estimation done by Thiobarbituric acid reactive substance (TBARS) (Buege and Aust,1978) method and vitamin C determined by the method of Natelson, (1971) and Vitamin E by Baker and Frank method.
Results: Majority of patient were between age group 41 to 60 years. Here, Mean MDA, Vitamin-C and E Level in case and control was 7.09±2.15 and 2.3±1.06; 0.225±0.067 and 0.998 ± 0.19 and 0.456±0.155 and 1.02±0.167 respectively.
Conclusion: Maxilla and vocal cord cancer is a major cause of morbidity and mortality in both developingand developed countries. We found an associations of vitamin C (Ascorbic acid), vitamin E (Tocopherol) and MDA with oral cancer.
Keywords: MDA, Oxidative stress, Vitamin-C, Vitamin-E.
Materials and Methods: Total 100 patients were selected.
Inclusion Criteria: Study included Maxillary and Vocal cord patient.
Exclusion Criteria: The exclusion criteria were male factor chronic disease like chronic heart disease (CHD), hypertension, ischemic heart disease, diabetes mellitus (DM), chronic obstructive pulmonary disease (COPD), other major systemic illness in different age group. MDA estimation done by Thiobarbituric acid reactive substance (TBARS) (Buege and Aust,1978) method and vitamin C determined by the method of Natelson, (1971) and Vitamin E by Baker and Frank method.
Results: Majority of patient were between age group 41 to 60 years. Here, Mean MDA, Vitamin-C and E Level in case and control was 7.09±2.15 and 2.3±1.06; 0.225±0.067 and 0.998 ± 0.19 and 0.456±0.155 and 1.02±0.167 respectively.
Conclusion: Maxilla and vocal cord cancer is a major cause of morbidity and mortality in both developingand developed countries. We found an associations of vitamin C (Ascorbic acid), vitamin E (Tocopherol) and MDA with oral cancer.
Keywords: MDA, Oxidative stress, Vitamin-C, Vitamin-E.