Anticataract activity of pioglitazone by using in-Vitro goat lens model

Authors : Rinkal R. Aware, Hemant J. Pagar, Ganesh D. Barkade, Shweta Dhawane

DOI : 10.18231/j.ijpp.2021.036

Volume : 8

Issue : 3

Year : 2021

Page No : 208-211

In the present study we have selected antioxidants agents like Pioglitazone and Ascorbic acid were subjected for anti-cataract activity by in vitro glucose induced cataract model. In the procedure, goat lenses was incubated along with the aqueous humor solution containing 55mM glucose with Enalpril as a standard compound and Pioglitazone with varied concentration for the time interval of 72 hours at room temperature. There was a formation of blur layer on the goat eyeball occurs after 10-12 hours and this process complete after 72 hours. The cataract inducing lenses showing higher level of Na, MDA (P<0>


Keywords: Anticataract, Antioxidants, Enalpril, Free radicals, In vitro, Pioglitazone


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