Primary pulmonary NUT midline carcinoma and its diagnostic challenges: A case report

Authors : Usha Ganugapati, Dominic Ong

DOI : 10.18231/j.ijpo.2022.085

Volume : 9

Issue : 4

Year : 2022

Page No : 353-356

NUT midline carcinoma (NMC) is a rare and aggressive cancer genetically characterized by a chromosomal rearrangement of the NUT gene. Primary pulmonary NMC is even more rare. NMC typically presents with histological features of a poorly differentiated squamous cell carcinoma. We report a case of a 23-year-old female patient with NMC in the lung and pleura presented to a midsize, midwestern Canadian hospital. This article emphasizes the diagnostic challenges posed by NMC and highlights an encounter with this aggressive cancer, which had not previously been diagnosed in our health region.
 

Keywords: NUT, BRD4, NUT midline carcinoma (NMC)


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