Chondrosarcoma of the great toe clinically mimicking osteoclastoma-An unusual presentation

Chondrosarcoma is cartilage forming neoplasm which mostly occurs in pelvis, femur and humerous. Chondrosarcoma is rare in the foot and the involvement of phalanges is extremely rare. It is a malignant neoplasm which mimics various epiphysial tumors clinically and radiologically, so histopathology is the gold standard for confirming the diagnosis. We report an unusual case of Grade II Chondrosarcoma in a 60 years old male, who complained of swelling and pain in left great toe for the past two years, which clinically mimicked Osteoclastoma. Imprint smear from swelling in the left great toe showed scattered mononucleated to binucleated oval to plump to polygonal cells with coarse chromatin and moderate eosinophilic cytoplasm in a chondromyxoid background suggestive of malignancy with differentials of Osteosarcoma and Chondrosarcoma. Histomorphology with immunohistochemistry led to the confirmation of diagnosis of this tumor at a rare site.


Keywords: Chondrosarcoma, Osteoclastoma, Osteosarcoma, Immunohistochemistry, Great Toe