Authors : Bharath Kumar A., Girendra Kumar Gautam, Syed Salman B
DOI : 10.26452/ijrps.v10i4
Volume : 11
Issue : 4
Year : 2020
Page No : 8119-8130
Pellets are defined as the spherical or semispherical solid dosage forms with the free-flowing property whose size ranges from 500–1500 µm. In recent days the pellets are being developed as immediate, modified and controlled release dosage forms due to their enormous range of advantages, i.e., in terms of both technological and therapeutical aspects. In the pelletization technique, fine powder of the active ingredient along with the excipients undergoes agglomeration to produce a small spherical or semispherical solid unit, i.e., pellets. There are various techniques for the formulation of pellets including drug layering, spray drying and congealing, cryopelletization, hot-melt extrusion, and freeze pelletization. The major aim of this paper is to review some general aspects regarding pellet and pelletization techniques like Drug Layering Technique, Spray Drying and Congealing, Cryopelletization, Extrusion Spheronisation, Hot Melt Extrusion, and Freeze Pelletization along with their advantages, disadvantages, and applications. This review also discusses the evaluation parameters like shape and surface morphology, pellet flow property, particle size distribution, porosity, friability, hardness, loss on drying, drug release studies, drug content of pellets, stability studies, moisture content of pellets, drug–excipient compatibility studies, as well as marketed pellet products and various patents on pellets.