Authors : Mrynal Chamoli1, Mohammed Junaid Khan2, Atul Arunrao Kulkarni3, Thirumalaikumaran Rathinam4, Avula Dhamini5, Tushar Pradip Dukre6, Vikas Kumar7, Saurabh Dave8*
DOI : 10.62441/nano-ntp.v20i7.4226
Volume : 20
Issue : 7
Year : 2024
Page No : 1781-1789
Turmeric (Curcuma longa L.) has a naturally occurring yellow substance called curcumin. However, in vitro tests have demonstrated a number of outstanding pharmacological properties, including anti-inflammatory, anti-tumor, antimicrobial, and antioxidant properties. Because beta-cyclodextrin (BCD) has advantages like improving drug release and/or permeation and stabilising drugs in the formulation or at the absorptive site, it is crucial to use BCD to form inclusion complexes that will increase curcumin's ability to penetrate the membrane upon transdermal administration. Curcumin and beta-CD inclusion complexes were made using a solvent evaporation technique with mole ratios of 1:1, 1:2, and 2:1. Using physical characterisation of X-ray diffraction, differential scanning calorimetry, and a scanning electron microscope, the solids of the curcumin inclusion complex that produced the beta-CD were compared to the curcumin single component, beta-CD, and a physical mixture of curcumin-beta- CD. Curcumin-beta-CD inclusion complex formation is indicated by a mole ratio of 1:2, according to physical characterisation data. Curcumin-beta-CD is utilised in inclusion complexes to improve the stability and solubility of curcumin.