Authors : Ismail Tawfeek Badr, Mohamed Kamal Mesregah, Sanjiv Rampal, Mahmoud Mohamed Moawad, Bahaa Zakarya Hasan
DOI : 10.2106/jbjs.cc.25.00546
Volume : 16
Issue : 1
Year : 2026
Page No : e25.00546
Case: A 27-year-old man presented with an 8-year history of chronic right gluteal and posterior thigh pain, worsened by sitting and unresponsive to conservative treatment. Imaging revealed widespread melorheostosis and osteopoikilosis of the right lower extremity, with 2 gluteal soft tissue masses compressing the sciatic nerve. The masses were excised using a dual surgical approach, achieving successful sciatic nerve decompression. Postoperatively, the patient regained normal sitting and sleeping tolerance, with complete pain relief maintained over a 15-month follow-up. Conclusion: Melorheostosis, a rare sclerosing bone disorder sometimes associated with osteopoikilosis, may require surgery when large lesions cause nerve compression.