Authors : Md Ikbal Husain and Biplab De
Volume : 10
Issue : 1
Year : 2025
Page No : 39-43
Life and death are not sudden events; rather, they are a series of irreversible chemical changes for normal event. There are many unexplained issues related to DNA-RNA, Neuroscience, Soul, life after death etc. knocking almost everyone, then also both the event of life and death have been continuing and continuing under the control of nature. For centuries, both philosophers and scientists have been interested in figuring out the initial stage of this process of death in normal cases. According to recent research, mitochondrial dysfunction more precisely, the opening of the mitochondrial permeability transition pore (mPTP) is the first irreversible event in cellular death. This review explores the biochemical, physiological and philosophical implications of defining the starting point of death. It highlights the cellular conditions necessary for life, the mitochondrial processes that cause permanent harm and how these scientific understandings relate to philosophical viewpoints regarding the nature of life's end. In addition to defining mortality, an understanding of the initial irreversible event of death gives therapeutic opportunities for reducing pathological cell death in serious disorders