Authors : Cristian-Catalin Gavat
DOI : 10.3390/iocn2023-14442
Volume : 60
Issue : 14
Year : 2023
Page No : 1-7
The aim of this paper was to exactly quantify the amount of pure ketoprofen within a pharmaceutical by a newly developed ultraviolet (UV)spectrophotometric method. The maximum ab sorption wavelength was determined to be = 254 nm for a ketoprofen alcoholic standard solution of 1.4 µg/mL. The applied method was statistically validated. The amount of pure ketoprofen assigned on the pharmaceutical tablet was found to be 146.326 mg ketoprofen/tablet. This obtained value was very close to the official declared content of active substance (150 mg pure ketoprofen/tablet), with an average percentage deviation of 2.45%—below the maximum value (± 5%). Keywords: ultraviolet (UV) spectrophotometric method; pure ketoprofen; pharmaceutical tablet; official declared content; active substance; average percentage deviation