Authors : M Raghavendra Rao, Monisha Basavaraju, Ranjitha Shankare Gowda
DOI : 10.18231/j.ijmmtd.2025.008
Volume : 11
Issue : 1
Year : 2025
Page No : 52-58
Aim and objective: To detect the production of carbapenemases among carbapenem resistant (CR) Klebsiella and Acinetobacter spp. and also to know the susceptibility of CR A. baumannii and K. pnuemoniae to fosfomycin. Introduction: Multidrug and carbapenem resistance is an increasing problem worldwide, which are most commonly seen in Klebsiella and Acinetobacter in the health care setting. Due to this reason, the interest in older antimicrobial agent, like fosfomycin has increased (1)(7). Acinetobacter species generally exhibit intrinsic resistance to fosfomycin, combining it with other antibiotics can often make it effective against these bacteria, particularly with multidrug-resistant strains, as fosfomycin can act synergistically with other agents to enhance its antibacterial activity. Materials and Methods: This is a prospective study conducted over a period of 1 year (Jan-Dec 2019) which included 120 Clinical isolates of CR Acinetobacter baumanii and Klebsiella pneumoniae that were collected from the patients admitted to a tertiary care hospital, Mysuru, Karnataka, South India. These isolates were subjected to phenotypic methods like CARBA NP (13) and CARB-ACINETO NP (14) for K. pnuemoniae and A. baumannii respectively, to detect the carbapenemase production and also subjected to fosfomycin susceptibility testing. Result: of the 57 CR A. baumannii, about 48(84.21%) were positive and 9(15.7%) were negative for CarbAcineto NPmethod. And about 48(84.22%) were sensitive and 9(15.78%) were resistant to fosfomycin. Of the 63 CR K.pnuemoniae, about 50(79.63%) were positive and 13(20.63%) were negative for CARBA NP method. And about 56(88.89%) were sensitive and 7(11.11%) were resistant to fosfomycin.