THE FUTURE OF NON-INVASIVE WAYS TO TREAT CANCER
The non-invasive technique in which a variety of nanoparticles
are used to deliver the chemotherapy drug to the location of metastatic cancer
has fewer side effects, high bio-availability, and high bio-stability of a drug. The
anti-proliferative activity of EGCG is very efficient against a variety of cancer,
but the problem is that it can’t withstand the environment of an intestine. One of
the nano-system is Spanlastic (type of niosome system) which can carry both
lipophilic and hydrophilic drugs. Spanlastic is capable of holding a large amount
of drugs; also, the penetration potential of spanlastic is very efficient due to the
addition of cholesterol and ethanol in it. Non-ionic surfactant made up of Span60 (mono-stearate), and the edge activator made of Tween-80 increases the
flexibility and deformability of the system. Ethanol injection will be used to
prepare the EGCG loaded spanlastic system. After preparing, the Z-average
diameter, polydispersity index, and spanlastic will be determined by dynamic
light scattering (DLS) and, with the help TEM imaging, will check the shape and
size of the system. Further, the system will be tested against SIF and SGF
incubators to calculate the cellular antioxidant activities and FRAP. Detection of
apoptosis will be checked by Annexin V–FLUOS staining kit. The EGCG
loaded in spanlastic will treat cancer and many other diseases as EGCG has
many other healing properties.
are used to deliver the chemotherapy drug to the location of metastatic cancer
has fewer side effects, high bio-availability, and high bio-stability of a drug. The
anti-proliferative activity of EGCG is very efficient against a variety of cancer,
but the problem is that it can’t withstand the environment of an intestine. One of
the nano-system is Spanlastic (type of niosome system) which can carry both
lipophilic and hydrophilic drugs. Spanlastic is capable of holding a large amount
of drugs; also, the penetration potential of spanlastic is very efficient due to the
addition of cholesterol and ethanol in it. Non-ionic surfactant made up of Span60 (mono-stearate), and the edge activator made of Tween-80 increases the
flexibility and deformability of the system. Ethanol injection will be used to
prepare the EGCG loaded spanlastic system. After preparing, the Z-average
diameter, polydispersity index, and spanlastic will be determined by dynamic
light scattering (DLS) and, with the help TEM imaging, will check the shape and
size of the system. Further, the system will be tested against SIF and SGF
incubators to calculate the cellular antioxidant activities and FRAP. Detection of
apoptosis will be checked by Annexin V–FLUOS staining kit. The EGCG
loaded in spanlastic will treat cancer and many other diseases as EGCG has
many other healing properties.