Authors : Syed Saif Imam
DOI : 10.13040/IJPSR.0975-8232.12(9).4684-96
Volume : 12
Issue : 9
Year : 2021
Page No : 4684-4696
The non-invasive technique in which a variety of nanoparticles are used to deliver the chemotherapy drug to the location of metastatic cancer has fewer side effects, high bio-availability, and high bio-stability of a drug. The anti-proliferative activity of EGCG is very efficient against a variety of cancer, but the problem is that it can’t withstand the environment of an intestine. One of the nano-system is Spanlastic (type of niosome system) which can carry both lipophilic and hydrophilic drugs. Spanlastic is capable of holding a large amount of drugs; also, the penetration potential of spanlastic is very efficient due to the addition of cholesterol and ethanol in it. Non-ionic surfactant made up of Span60 (mono-stearate), and the edge activator made of Tween-80 increases the flexibility and deformability of the system. Ethanol injection will be used to prepare the EGCG loaded spanlastic system. After preparing, the Z-average diameter, polydispersity index, and spanlastic will be determined by dynamic light scattering (DLS) and, with the help TEM imaging, will check the shape and size of the system. Further, the system will be tested against SIF and SGF incubators to calculate the cellular antioxidant activities and FRAP. Detection of apoptosis will be checked by Annexin V–FLUOS staining kit. The EGCG loaded in spanlastic will treat cancer and many other diseases as EGCG has many other healing properties.