Authors : Lalit Kumar, Nupur Kaushik, Rajdeep Singh, Harendra Kumar, Ashish Gautum
DOI : 10.18231/j.achr.2022.020
Volume : 7
Issue : 2
Year : 2022
Page No : 94-99
Introduction: In China, Wuhan City became the epicentre of unexplained cases of pneumonia in December 2019 and was temporarily labelled as, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). World Health Organization renamed it to coronavirus disease 2019 (COVID-19) in February 2020. In COVID-19 patients hematological profile showed increased total leukocyte count (TLC) and neutrophilic count, while decrease in other hematological parameters. The mild increase in TLC was found in severe disease patients; however significant increase was associated with clinical worsening and poor outcome. Significant elevation of various biochemical and inflammatory markers was noticed among COVID-19 patients
Materials and Methods: We conducted a retrospective study on RT-PCR confirmed 239 COVID-19 patients who were hospitalized in various COVID-19 facilities from Sept 2020 to Dec 2020. The laboratory data is used in de-identified form and doesn’t reveal identity of any subjects.
Results: A total of 239 cases were examined, out of which 176(73.7%) were male and 63(26.3%) were female (M:F ratio= 2.79:1). We found that 104 cases had Hb level ? 12gm/dl. We found that maximum patients (175) had TLC level >11000/cumm, 187 patients had ANC level > 7000/cumm. We found that 160 cases had serum urea of >43mg/dl, 134 case with serum creatinine of >1.4gm/dl.134 cases had ALT level of >40IU/L and 143 cases had AST levels of >42IU/L In this study out of 239 cases 126 cases were found to have increased level of all inflammatory markers levels.
Conclusion: We found a significant association of various inflammatory markers with haematological and biochemical parameters in COVID-19 patients.
Keywords: SARSCoV2 infection, Procalcitonin, Ferritin, Ddimer, Lactate dehydrogenase