Proxidant and Antioxidant Status in Patients of Type II Diabetes Mellitus with IHD

Patients with type II Diabetes Mellitus (NIDDM) are more prone to Ischaemic Heart Disease (IHD). Although,
oxygen free radicals are known to contribute to the development of IHD, conflicting reports are available
regarding the antioxidant status in patients of NIDDM complicated with IHD. This study was undertaken to
investigate the oxidative status in patients of NIDDM and to assess their correlation with plasma glucose,
glycosylated haemoglobin and duration of diabetes. The levels of malondialdehyde were significantly increased
where as levels of superoxide dismutase, Glutathione peroxidase and vitamin C were significantly decreased
in diabetics without complications and non-diabetics with IHD when compared with the controls. The levels of
malondialdehyde and Glutathione peroxidase were significantly increased where as levels of superoxide
dismutase and vitamin C were significantly decreased in diabetics with IHD when compared with diabetics
without complications and non-diabetics with IHD. The implications of the results are discussed.