Ketofol: what is it?

Authors : Somchai Amornyotin

DOI :

Volume : 49

Issue : 2

Year : 2023

Page No : 69-71

Ketofol is the combination of ketamine and propofol in several concentrations. This combination has several ideal anesthetic properties. Numerous clinical studies of the use of ketofol have been evaluated. To date, there is significant interest in ketofol as an agent for procedural sedation. It is commonly utilized for several procedures. Ketamine, a neuroleptic anesthetic agent, works on thalamocortical and limbic N-methyl-D-aspartate (NMDA) receptors. It can be given through intravenous or intramuscular routes. Propofol, a sedative, hypnotic and anesthetic agent, is also an antagonist at NMDA receptors. Propofol is a 2,6-diisopropyl phenol with sedative-hypnotic properties. It is highly lipophilic and distributes extensively in the body. With an attractive pharmacokinetic profile of rapid onset and offset, propofol has a place in medical and dental care.