Authors : Madhur Gupta, Suresh Chari
Volume : 3
Issue : 1
Year : 2016
Page No : 70-73
Abstract Introduction: Pre-eclampsia is a systemic infl ammatory condition associated with maternal endothelial dysfunction. Matrix metalloproteinase (MMP) results in a poor trophoblastic invasion of the maternal spiral arteries, poor fetoplacental perfusion, and release of factors which aff ect the vascular tone and remodeling. Objectives: To compare the serum values of MMP-1, tissue inhibitor of metalloproteinase (TIMP)-1, and their ratio in the second and third trimester of normal and pre-eclamptic pregnancy. Materials and Methods: 30 females progressing to normal pregnancy were compared with 16 females who developed preeclampsia. MMP-1 and TIMP-1 concentrations were measured in serum samples (II and III trimester) of the females by enzyme linked immuno-sorbent assay. Results: There was no signifi cant diff erence in the levels of MMP-1, TIMP-1, and ratio of MMP-1 and TIMP-1 in pre-eclamptic and normal pregnancy females. Conclusion: There is a lack of alteration in the levels of MMP-1, TIMP-1, and their ratio during the progression of pre-eclampsia when compared with normal pregnancy. Further studies with a larger sample size are required to validate this data. Key words: Pre-eclampsia, Matrix metalloproteinase-1, Tissue inhibitor of metalloproteinase-1