Association between C-reactive Protein and Interleukin-6 Levels in Subclinical Hypothyroid Patients.
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Table of Contents
ORIGINAL ARTICLE
Year : 2018 | Volume : 13 | Issue : 4 | Page : 195-198
Association between C-reactive protein and interleukin-6 levels in subclinical hypothyroid patients
Satya Devi Uppu, Madhur Gupta
Department of Biochemistry, NKP Salve Institute of Medical Sciences and Research Centre, Nagpur, Maharashtra, India
Date of Web Publication 16-Apr-2019
Correspondence Address:
Dr. Madhur Gupta
Department of Biochemistry, NKP Salve Institute of Medical Sciences and Research Centre, Digdoh Hill, Hingna Road, Nagpur - 440 019, Maharashtra
India
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Source of Support: None, Conflict of Interest: None
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DOI: 10.4103/jdmimsu.jdmimsu_6_18
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Abstract
Background: The relationship between subclinical hypothyroidism (SCH) and cardiovascular disease has been one of the most popular topics recently. Our study aims to investigate the presence of the well-known preceding clinical situations of atherosclerosis such as endothelial dysfunction and inflammation in SCH.
Materials and Methods: The study population comprised 50 patients with recently diagnosed SCH and 50 healthy controls. Thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were estimated by enzyme-linked fluorescent immunoassay for the diagnosis of SCH. Total cholesterol (TC), triglycerides, and high-density lipoprotein cholesterol (HDLC) were estimated by kit method in Siemens machine. Low-density lipoprotein cholesterol (LDLC) and very LDLC were calculated using Friedewald formula. Inflammatory marker C-reactive protein was estimated by kit method in Siemens and IL-6 by enzyme-linked immunosorbent assay.
Results: In this study, the level of TSH ± standard deviation (8.56 ± 1.26 vs. 0.63 ± 0.16) was significantly higher (
Table of Contents
ORIGINAL ARTICLE
Year : 2018 | Volume : 13 | Issue : 4 | Page : 195-198
Association between C-reactive protein and interleukin-6 levels in subclinical hypothyroid patients
Satya Devi Uppu, Madhur Gupta
Department of Biochemistry, NKP Salve Institute of Medical Sciences and Research Centre, Nagpur, Maharashtra, India
Date of Web Publication 16-Apr-2019
Correspondence Address:
Dr. Madhur Gupta
Department of Biochemistry, NKP Salve Institute of Medical Sciences and Research Centre, Digdoh Hill, Hingna Road, Nagpur - 440 019, Maharashtra
India
Login to access the Email id
Source of Support: None, Conflict of Interest: None
Crossref citations Check
DOI: 10.4103/jdmimsu.jdmimsu_6_18
Rights and Permissions
Abstract
Background: The relationship between subclinical hypothyroidism (SCH) and cardiovascular disease has been one of the most popular topics recently. Our study aims to investigate the presence of the well-known preceding clinical situations of atherosclerosis such as endothelial dysfunction and inflammation in SCH.
Materials and Methods: The study population comprised 50 patients with recently diagnosed SCH and 50 healthy controls. Thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were estimated by enzyme-linked fluorescent immunoassay for the diagnosis of SCH. Total cholesterol (TC), triglycerides, and high-density lipoprotein cholesterol (HDLC) were estimated by kit method in Siemens machine. Low-density lipoprotein cholesterol (LDLC) and very LDLC were calculated using Friedewald formula. Inflammatory marker C-reactive protein was estimated by kit method in Siemens and IL-6 by enzyme-linked immunosorbent assay.
Results: In this study, the level of TSH ± standard deviation (8.56 ± 1.26 vs. 0.63 ± 0.16) was significantly higher (