Koushlesh Kumar Mishra

Abstract

Nowadays, herbs used worldwide due to its medicinal and pharmaceutical potentials. Herbs are also used to prevent human beings from variety of diseases. In the current study, alcoholic extract of which is commonly known as green chiretta used in the development of handwash (herbal). Traditionally, green chiretta was used and known for their different pharmacological action. Alcoholic extract of loaded herbal hand wash prepared by using Carbopol-934 as gelling agent, TEA (triehanolamine) as neutralizer and sodium lauryl sulfoacetate (SLSA) as surfactant. Antibacterial activity of herbal handwash gel evaluated by cup plate method. Sthaphylococcus aureus, Escherihia coli and Bacillus subtilis are used to assess the potential of gel against microorganisms. It shows good potential action against Bacillus subtilis. Physicochemical characterization of herbal handwash gel was performed by morphological study such as odor, color, pH, foam height, consistency and retention as per chemical standards. The developed herbal hand wash formulation showed no side effects and outcomes are in the limits.   Keywords: Andrographis paniculata, B subtilis, Handwash gel, Antibacterial activity

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Abstract

In this study the hydro-alcoholic extract of the plant Cynodon dactylon (L.) Pers. was undertaken to evaluate the wound healing property on Burn Wound Model and to compare the effect of the combination of hydro-alcoholic extract of Cynodon dactylon (L.) Pers. and Silver Sulphadiazine with Silver Sulphadiazine alone. Six groups are made and each group consist of 6 animals in it. Each animal of all the six group is inflicted with partial thickness burn wound. The group is numbered as Group I to Group VI. The animals in Group I are taken as control where no drug is given to them. To the Group II animals’ Standard silver sulphasalazine is given. In case of group III animals, they are subjected to hydro-alcoholic extract of Cynodon dactylon. Animals in Group IV and Group V received pure ethanolic extract and aqueous extract respectively. In case of Group VI animal they are treated with standard drug as well as extract. The study mainly focuses on observing parameters like period of epithelialization and the wound contraction percentage. It is observed that the animals in the group which received both hydro alcoholic extract and sulphadiazine showed an improved burn wound contraction. In addition to it the group IV and V shows a decreased epithelialization period. Keywords: Cynodon dactylon (L.) Pers., Epithelialization, hydro-alcoholic extract (HAE), Silver Sulphadiazine, Wound contraction.

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