Dr. Shoheb Shakil Shaikh

In the India there is a good biodiversity in plants. Plants based medicinal products used as integrated part of treatment on most of traditional systems of medicines. Sesbania grandiflora is a plant which used traditionally for many medicinal used which belongs in family Fabaceae. Present study was about investigated the Physicochemical and Phytochemical studies on selected plant such as Sesbania grandiflora. For the study Soxhlet apparatus was used for extraction of plant materials with using water, ethanol and chloroform as extractive solvents. Standard chemicals and methods were used for the qualitative determination of plant S. grandiflora flowers extract. The study investigation was followed to determine the presence of chemical compound in flowers part of plant as well as to investigate the quality of drug. Result found that the different flower extract may presence of alkaloids, steroids, tannins, sterols, flavonoid etc. The pentylenetetrazol (PTZ) induced seizure model was used for testing anticonvulsant activity of ethanolic, aqueous and chloroform extracts(100mg/kg) of Sesbania grandiflora flowers. The extracts significantly (*p < 0> Keywords: Sesbania grandiflora, Flowers, Fabaceae, Phytochemical screening, Physicochemical parameters, Anticonvulsant activity

Launaea sarmentosa has been extensively used as a nutrient herb in traditional Vietnamese remedies for the treatment of various diseases. (Wild.) are widely used plants in Asian folk and traditional medicines. In the present study, we have tried to find out the Phytoconstituents, wound healing activity of the Ethanolic extracts of these plants. It’s been showed that totally different a part of Launaea sarmentosa species as well as leaves, flowers, seed, root, and aerial half possess ethno botanic values could be a crawl herb, native to coastal areas in India, Africa (east coast, Mauritius, and South Asia etc. Keywords: Launaea sarmentosa (Asteraceae), Ethanolic extract, Phytoconstituents

A simple reverse phase liquid chromatographic method with ultraviolet detector was developed for the accurate determination of Valacyclovir using GracesmartRP18, C18 Column (250 mm × 4.6 mm, 5?m particle size). The mobile phase used for the determination was Methanol: Citric Acid buffer in a ratio of 60: 40 v/v at a flow rate of 1.0 mL per min. Valacyclovir was eluted at 2.2 ± 0.1 min and detected at 254 nm. The method is linear over the concentration range of 10-50 µg/mL with correlation co-efficient r = 0.999. The plate count and tailing factor was found 3847 and 1.24 respectively. The developed method was proved to be robust after extensively validated with different parameters such as Linearity, Precision, Accuracy, Robustness, Ruggedness, Limit of Detection (LOD), Limit of Quantification (LOQ) and specificity. The validated method is definite, meticulous and reproducible and can be used for routine analysis of Valacyclovir in bulk form. Keywords: Valacyclovir, C18 Column, Methanol: Citric Acid buffer (60:40), UV detector254nm

Frequent use of synthetic hair care products and overuse of grooming results in damaged hair. This leads to growing demand for natural hair care products. Many synthetic harsh chemicals in liquid shampoo leads to dry and damaged hair. An attempt was made to formulate a conditioning shampoo bar with safflower oil. The nutrient rich, weightless oil imparted good conditioning and smoothness to rough hair surface indicated by SEM studies of treated hair with conditioning shampoo bar containing 5% oil. Formulated shampoo bars are found to have various desirable properties like moisturizing, conditioning and nourishing effect on the dry and damaged hair with good grooming, luster, manageability and shine. Keywords: Conditioning shampoo bar, Conditioning, Safflower oil