Tshetiz Dahal

Abstract

Aim: According to earlier research, tumour response, Lymphocytopenia, and a system-wide immune-inflammatory indexes all affect the clinical results of Stage III NSCLC. We postulated that the tumour response to CRT would be related to hematologic parameters and could perhaps anticipate clinical results. Materials and Methods: Retrospective evaluation of stage III NSCLC patients treated at a single facility between 2015 and 2020 was done. After receiving CRT, the pre-treatment gross tumour volume (GTV) was measured again. Full blood counts were taken before, during, and after treatment. Neutrophil platelet lymphocyte was used to define the systemic immune-inflammation index (SII). Kaplan-Meier estimates were used to compute overall survival (OS) and prognosis-free survival (PFS), which were then compared using Wilcoxon tests. Then, taking into account additional baseline parameters, pseudovalue regression was used to provide a multivariate study of hematopoietic factors affecting controlled average duration. Results: There were 110 patients in total. The median PFS and OS were 20 and 35 months, respectively, after a median follow-up of 24 months. Baseline SII was correlated with OS (p = 0.039) but not PFS (p = 0.10), and baseline ALC was correlated with both PFS and OS (p = 0.13 and p = 0.06, respectively) in the multivariate model. The recovery SII, nadir ALC, and nadir SII were not connected to PFS or OS. Conclusion: Baseline hematologic variables, such as baseline ALC, baseline SII, and recovery ALC, were related to clinical outcomes in this cohort of patients with stage III NSCLC. The relationship between disease response and hematologic variables or clinical outcomes was not strong.   Keywords: Lymphocytopenia, Myelosuppression, Chemoradiation, Inflammatory, Tumor­response, NSCLC, Immune

Open full article page

Abstract

Background: Major health issues in the contemporary world, thyroid illnesses are distinguished by changes in hormone output, thyroid gland hypertrophy, or both. The purpose of this study was to identify thyroid histological patterns in people who had thyroid surgery. Materials and Methods: At Kathmandu University Hospital, a retrospective study was conducted over a two-year period, from January 10, 2021, to December 30, 2022. This study includes all 300 patients who underwent thyroid surgery. gender, age, residency, the outcome of a fine needle aspiration biopsy (FNAB), and post-operative histological patterns were all taken into account. Patients who underwent FNA exclusively were ineligible. Results: Participants' average ages ranged from 35.06 ± 15.19 years. Thyroid disorders were more frequently found in females (90%) than in males ( 10%). Nodular colloid goitre (65.1%), adenoma (5.8%), papillary thyroid neoplasms (25.4%), follicular thyroid carcinoma (6.8%), medullary thyroid carcinoma (8.5%), thyroiditis (9.3%), and anaplastic thyroid cancer (3.9%) were the histopathologic patterns. With a prevalence of 64 (23.1%), papillary thyroid cancer was the most prevalent type. The combined accuracy of the final histology and FNAB was 90.04%. However, 50% of follicular cancer preoperative diagnoses made by FNAB were insufficiently accurate. While FNAB specificity varied from 95.1% to 98.9%, FNAB sensitivity ranged from 75.8% to 90.8%. Conclusion: The most common thyroid condition is nodular colloid goitre, while papillary thyroid carcinoma is the most common cancer seen in this study. We suggest more research with a bigger sample size to confirm our findings.   Keywords: Goiter, Histopathology, Papillary carcinoma, Thyroidectomy, Hormone, Thyroid

Open full article page