Sushma Shankar

Abstract

Aim: To study the association between the ABO blood groups and clinicopathological features in cases of prostate cancer (PCa). Materials and Methods: Fifty cases of PCa, diagnosed on transurethral resection of prostate chips were a part of the study. Cases were classified into low risk and high risk categories and these categories were compared with the clinicopathological features and ABO blood groups. Results: In the study of 50 cases, 44 cases belonged to the high risk category with 33(75%) patients being of non O blood group and 11(25%) being of the O blood group. Patients of non O group had an increased risk of aggressive PCa on comparison with the blood type O. Chi sqaure test showed no significant difference between the non O and O groups regarding PSA value, Gleason score, tumor stage, node positivity and bone metastasis individually (p=0.418, p=0.967, p=0.506,p=0.775, p=0.549.) However within the high risk category, a statistically significant value was found for non O blood group against O groups (p=0.04) which was further proven by regression analysis. Conclusion: In this study, non O blood types (especially A and B but not AB) were found to be independent predictors for high risk PCa and O blood type patients had a low risk of aggressive PCa thus emphasising the importance of blood typing in patients with PCa. Keywords: Prostate cancer (PCa), ABO blood type, O blood type, Non O blood type.

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Abstract

Aim: To study the significance of neutrophil- lymphocyte ratio (N:L ratio) in prostate lesions, especially in cases of prostate cancer (PCa). Materials and Methods: Fifty cases of PCa and fifty cases of benign prostatic hyperplasia (BPH), diagnosed on transurethral resection of prostate biopsies were included in the study. Hematological parameters were recorded, N:L ratio was calculated in all cases and values were compared between BPH and PCa, further association between pathological characters of PCa and N:L ratio values was studied. Results: In the present study, we found a statistically significant high N:L ratio in PCa cases as compared with BPH cases (p=0.008). We also found a significant difference in the PSA values (p<0.001) and ESR (0.001) between the benign and malignant groups. However hemoglobin, platelet counts and total leucocyte counts did not show a significant difference between the two groups. Sub group analysis failed to show an association between prognostic markers like PSA (p=0.838), gleason score (p=0.161), T (p=0.052) N (p=0.225) M (p=0.529) stage and N:L ratio. Conclusion: In this study, significant difference in N:L ratio was noted between BPH and PCa, but no association could be demonstrated between N:L ratio and prognostic markers in PCa. Hence N:L ratio cannot be used as a prognostic marker in PCa. Keywords: Prostate cancer (PCa), N:L ratio.

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