Mohammad Asif

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Abstract

Among heterocyclic compounds, 1,3,4-oxadiazole has become an important synthons in development of new drugs. Compounds containing 1,3,4-oxadiazole cores have a broad biological activity spectrum, including antibacterial, antifungal, analgesic, anti-inflammatory, antiviral, anticancer, antidepressant, anticonvulsant, and anti-diabetic properties. The ability of 1,3,4-oxadiazole heterocyclic compounds to undergo various chemical reactions has made them important because of their privileged structure, which has an enormous biological potential.  Keywords: Heterocyclic compound, 1,3,4-oxadiazoles, Biological activities.

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Abstract

Various 1,3,4-thiazole derivatives have been reported to exhibit various biological activities. The 1,3,4-thiadiazole derivatives found to have diverse pharmacological activities such as, insecticidal, herbicidal, antiviral, anti-tumor, CNS stimulant, anti-bacterial, antifungal, antiangiogenic, antiglaucoma, antiischemic, and anti-inflammatory, antidepressant, anxiolytic, antiparasitic, antitumor, hypoglycemic, antihypertensive and CNS depressant activities The 1,3,4-Thiadiazoles have also been used in many fields and majority of applications as dyes, lubricants, analytical reagents and agents. The 1,3,4-Thiadiazole analogs are associated with diverse biological activities probably by virtue of toxophoric -N=C-S- group. Due to the wide range of applications we have studied thiadiazole derivatives for their biological significances. Keywords: Thiadiazoles, Pharmacological, Triazolo.

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