Preeti R Doshi

Abstract

Introduction: Liver biopsy contributes greatly to the understanding of liver diseases & is considered gold standard for evaluating liver disorders, providing information regarding diagnosis, disease progression and response to therapy. Objectives: 1). To study histomorphological features of liver biopsies and to correlate them with presenting co mplaints & radiological findings. 2). To document the pattern of various hepatic lesions. Results/Observations: A retrospective study of 66 liver biopsies during the period January 2013 to May 2015 was done. Sections were stained with H & E and examined under light microscope. Special stains were done in specific cases. Among these, 45 cases were males and 21 cases were females. Out of 66 cases, 24(36.3%) cases were hepatocellular carcinoma, 13(19.69 %) cases of glycogen storage disorder, 3(4.54%) cases each of fatty liver, hepatitis, cirrhosis & degenerative liver disease. 2(3.03%) cases of liver cell dysplasia and 1(1.51%) case each of biliary atresia , amyloidosis, miliary tuberculosis and liver abscess. Liver biopsy was non specific in 4(6.06%) cases & inadequate in 7(10.6%)cases. Conclusion: Microscopic examination of liver biopsy yields a diverse range of pathological findings and helps to uncover diseases for which specific management is indicated. Keywords: Hepatocellular carcinoma, Glycogen Storage Disorder, Liver biopsy.

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Abstract

Introduction: Various QC and QA including the pre analytical, analytical and post analytical variables were taken into consideration for the internal quality indicators in department of cytopathology of a tertiary care hospital. Aims: To evaluate the importance of quality control (QC) and quality assurance (QA) parameters in the routine work of cytology pathology laboratory in a tertiary care hospital. Materials and Methods: This is a retrospective and quantitative study in a tertiary care hospital for a period of one year for the analysis of the internal quality indicators for Cytopathology laboratory for gynaecological and non- gynaecological cases with selected variables. Results: Data was analyzed using various mentioned formulas and excel sheet along with review of literature in the cytopathology laboratory. Conclusion: It is very important to set the standards and review the procedures of QA and QC as per the requirement for the laboratory to ensure the quality for the cytopathology laboratory. Keyword: Cytopathology, Quality assurance, Quality indicators.

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