Authors: Victoria Kshetrimayum, Usha S M R, Vijayalakshmi P
Introduction: Thyroid disorders are one of the most prevalent endocrinopathies across the globe. As per the data of India Government, the prevalence of hypothyroidism is about 5.4%. Hypothyroidism is a common endocrine disorder encountered in clinical practice. Hypothyroidism (both clinical & subclinical) has been reported to be associated with inflammation, dyslipidemia which leads to CV risk. Hs-CRP is a marker of chronic subclinical inflammation and a predictor of CVD. The mechanism responsible for inflammatory process seen in hypothyroidism might be TSH induced produced production of TNF-a by a bone marrow cells. Aims and Objectives: To analyse the thyroid profile, hs-CRP and lipid profile in newly detected hypothyroid adults in comparison to controls and also to compare the above parameters in subclinical and clinical hypothyroid cases. Materials and Methods: A total of 164 subjects (82 hypothyroid cases and 82 euthyroid (controls), visiting General Medicine OPD, RRMCH, Bengaluru were consider for study. The subjects were selected based on thyroid profile-analysed by CLIA, hs-CRP by Immunoturbidimetric, Lipid profile was measured by spectrophotometric method. Statistical analysis was done using student’s “t” test and Pearson’s correlation. Result and Discussion: The study subjects were age matched (mean age 35 years) with female predominance. TSH value significantly increased in cases (p within the reference range. Serum hs-CRP levels though significantly increased in cases (p=0.005), were within the normal range. There was significant increase in LDL-c and TG (p (p positive correlation was found between TSH and hs-CRP (r=.275, p
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