Reena R

Abstract

Introduction: Physiological changes in lipid metabolism observed during pregnancy is exaggerated in preeclampsia (PE). The latest recommendations of European and American Cardiological Associations and National Cholesterol Education Program Adult treatment panel III (NCEP ATP III), emphasize the role of non-High-Density Lipoprotein cholesterol (non-HDL-C) in evaluating the risk of atherogenesis, as a marker of dyslipidemia, especially in presence of hypertriglyceridemia. The aim of this study was to measure non-HDL-C to assess dyslipidemia in PE, a state of hypertriglyceridemia. Materials and Methods: Study was conducted on fifty preeclamptic women and fifty age matched apparently healthy pregnant women attending the Antenatal clinic in Department of Obstetrics and Gynecology, Rajarajeswari Medical College and Hospital. Lipid profile was estimated in Erba auto analyzer EM 360 by enzymatic method and Non-HDL-C was calculated by subtracting HDL-C from Total cholesterol (TC). Results: Hypertriglyceridemia was observed in both the groups. Serum non-HDL-C level was 161.7644.74 mg/dl and 143.7521.80 mg/dl in cases and controls respectively. Non-HDL-C was increased moderately (p compared to controls. Despite of normal LDL-C, High non-HDL-C was observed in five preeclamptic women (12%). Conclusion: Dyslipidemia is observed in PE which results in atherogenesis and endothelial dysfunction. Non-HDL-C predicts dyslipidemia better than LDL-C in PE. The health of the mother and her fetus are intertwined, hence the non-HDL-C should be recommended to be a part of routine investigation during pregnancy, to institute prompt management strategies to prevent deleterious effects of dyslipidemia associated with PE. Keywords: Atherogenesis, Dyslipidemia, Lipid profile, Non-HDL-C, Preeclampsia.

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Abstract

Introduction: Insulin has its effect on the basal and stimulatory secretion of exocrine pancreatic enzymes. In this context this study has been done to understand the relationship between the exocrine and endocrine entities of pancreas by analyzing two most commonly estimated exocrine enzymes; serum amylase and serum lipase in type 2 DM. Materials and Methods: The study was conducted at Rajarajeswari Medical College and Hospital, Bengaluru, Karnataka from January 2012 to December 2012. Hundred clinically diagnosed cases of type 2 diabetes mellitus {Fifty well controlled (HbA1c < 7> Results: Serum amylase and serum lipase levels were within the reference range in all the three study groups. There was no significant difference in serum amylase among well controlled and poorly controlled type 2 DM. In contrast, significant difference in serum amylase levels was observed between diabetic group and controls (p Conclusion: The potential underlying connection between exocrine and endocrine function of pancreas in patients with type 2 DM needs further investigation with larger population; to consider the analysis of serum pancreatic enzymes especially serum lipase levels as an additional informative parameter to assess the glycemic control in type 2 DM. Keywords: Type 2 DM, Serum amylase, Serum lipase.

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