Raj Kumar

Abstract

Modern life style is known to be responsible for sequence of manifestations like obesity and hyperlipedemia, hypercholesterolemia and atherosclerosis. Due to obesity, about 2.8 million people die every year worldwide. About 5% Indian were influenced by weight. This study includes 6Methodology for estimation of serum glucose 0 individuals, which includes 10 uncontrolled type-2 diabetic, 15 controlled type-2 diabetic, 15 obese and 20 healthy individuals. To study the lipid profile, creatinine, routine urine and fasting blood sugar for healthy, diabetic and obese subject various biochemical parameters like fasting blood sugar (FBS), total cholesterol (TC), triglyceride (TG), high density-lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), very low density lipoprotein cholesterol (VLDL-c), creatinine, and qualitative urine were analysis. In current study more numbers of patients with abnormal blood glucose and lipid profile found to belong to the age group of 30-60 years, 71% participants have abnormal blood glucose and lipid profile as compared to younger participants of age group 20-30 years, 6% younger participants have normal blood glucose and lipid profile. The present study clearly established that, diabetes along with obesity has a direct effect on the physiological functioning of liver and heart, which is proven by various tests. It is also noted that high consumption of fat results in the accumulation of fat in the body which can cause cardiovascular diseases. Diabetes along with obesity results increase in the concentration of cholesterol, triglyceride, LDL, VLDL and decrease in HDL, which are well established in the risk factor of cardiovascular disease. Keywords: Life style diseases, Serum creatinine, Serum cholesterol, Serum triglyceride.

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Abstract

Thyroid hormones (TH) are essential for an adequate development and kidney maturity. The dysfunction of thyroid causes striking changes in glomerular and tubular capacities and electrolyte and water homeostasis. Hypothyroidism is affiliated with a decline in glomerular filtration, hyponatremia, and a modification of the capacity for water extraction. Since various renal function derangements occur in hypothyroidism, therefore, present study has been intended to determine the various parameters (urea, creatinine and uric acid) related to renal function in hypothyroid patients and correlation of these parameters with thyroid hormones (T3, T4, TSH).  The study was conducted on 200 hypothyroidisms. Age and sex matched healthy euthyroids were selected for the study. Serum was taken from each patient and control and was analyzed for T3 by competitive analog-based immunoassay, T4 by competitive analog-based immunoassay, TSH by 2 site chemiluminescent immunometric assay, creatinine by modified Jaffe’s method, urea by urease method and uric acid by uricase method respectively. A total number of 300 cases that includes 200 hypothyroid patients (25% males and   75% females) and 100 controls (42% males and 58% females) were examined. The mean level of serum T3 (1.968 ± 0.1195 pg/ml), serum T4 (1.0152 ± 0.1235 pg/ml), serum urea (33 ± 5.570mg/dl) of hypothyroids were significantly lower as compared to mean level of serum T3 (3.704 ± 0.1699 pg/ml), serum T4 (1.5764 ± 0.16230 pg/ml) and serum urea (35.12 ± 3.710mg/dl) of euthyroids. The mean level of serum TSH (8.928 ± 0.9589µIU/ml) serum Creatinine (2.192 ± 0.2566mg/dl) and serum uric acid (4.224 ± 0.6554mg/dl) of hypothyroids were significantly higher as compared to mean level of serum TSH (3.06 ± 0.4110 µIU/ml), serum Creatinine (0.852 ± 0.1396 mg/dl) and serum uric acid (3.772 ± 0.2975 mg/dl) of euthyroids. Hypothyroids serum T3 significantly correlated with positive person serum uric acid (r = 0.343). Hypothyroids serum T4 indicate noteworthy negative Pearson relationship with serum urea (r = - 0.367) and creatinine (r = - 0.267) Hypothyroids serum TSH indicate huge negative Pearson connection with serum uric acid (r = - 0.190) and creatinine (r = - 0.344). Elevated serum creatinine, serum urea and serum uric acid demonstrates renal capacity disturbances in hypothyroidism. Keywords: Thyroid hormones, T3, T4, TSH, Serum creatinine, Serum uric acid.

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Abstract

Preeclampsia is a pregnancy specific syndrome which involves an increase of arterial blood pressure, accompanied by proteinuria, oedma or even both. This investigation was intended to compare the serum uric acid level in preeclamptic and normal pregnant women and its correlation with some important maternal and fetal results. The subjects were partitioned into two groups, Group I: control subjects normal pregnant women and Group II: pregnancy induced hypertensive women. Each groups consisted of 30 pregnant women of Uttar Pradesh (India). The blood sample was collected and analyzed for biochemical parameters, blood urea, serum uric acid, serum creatinine and total protein. The result data were dissected by using SPSS. The systolic (SBP) and diastolic blood pressure (DBP) and serum uric acid were significantly (P Keywords: Preeclampsia, Uric acid, Early-onset preeclampsia, Late-onset preeclampsia.

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