Authors: Satish Verma, Guru Prasad R, Neeta Sharma, Narottam Ghejta
Ewing's sarcoma is a small round-cell malignant tumor of bones, primarily affecting children and young adults. It might be neuroectodermally derived with various degrees of differentiation of the primitive neural tissues. It has retained the most unfavourable prognosis of all primary musculoskeletal tumors, with long-term survival being less than 10%. The development of multi-disciplinary therapy with chemotherapy, irradiation and surgery, the survival rates are increased to greater than 50%. The pathognomonic translocations involving the EWS gene on chromosome 22 and an ETS-type gene, which is the Fli1 gene on chromosome 11, are implicated in more than 95% of Ewing’s sarcomas. This paper reports a rare case of ES of mandible in 8years old male patient. The patient was managed with multiagent chemotherapy, followed by surgical resection. Keywords: Ewing’s sarcoma, Mandible, Malignant tumor, Surgery, Chemotherapy.
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