Authors: Sagar N Shahane
Introduction: Meningiomas are mostly benign tumour and major prognostic factor for recurrence is mostly dependent on the histopathological category, proliferation indices, grading and estrogen (ER) and progesterone (PR) receptor status. The present study was undertaken to find ER, PR receptor in excised specimen of meningioma and its correlation with Ki67 labelling index. Materials and Methods: 75 cases of meningioma collected over period of 2 years was subjected to Haematoxylin and Eosin staining for routine histopathological investigation and immunohistochemical staining against PR, ER and Ki-67 by means of mouse monoclonal antibodies. Ki-67 labelling index was determined and Histological grade, PR, ER receptor status was evaluated. Results: The Mean Ki-67 LI was significantly higher in PR-negative versus PR-positive meningioma, Grade II versus Grade I and males versus females. Whereas the PR positivity was significantly higher in Grade I versus Grade II and females versus males. A strong converse relationship was established between PR expression and Ki-67 LI. Conclusions: As per the results it has been revealed that immnodetection of ki-67 LI and PR expressions in meningiomas are the important indicators for assessing prognosis and recurrence rate in meningioms. Keywords: Meningiomas, Histopathology, Ki67, Progesterone, Estrogen, Haematoxylin, Eosin
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