Authors: Narayan Sah Sonar, N C Nagalakshmi, Hemalatha S, Hariprasad MG
Abstract
Liver act as metabolic factory of the body and metabolism of virtually every foreign substance. Its functioning is crucial for health and disease. Chemicals that cause liver injury are called hepatotoxicants. More than 950 drugs have been implicating in causing liver injury and were withdrawn from the market. Mechanism of hepatotoxicity induced by drug, immune based and genetic based toxicity. The drug models which are applied to study hepatotoxicity are Paracetamol, CCl4, Galactosamine, Alcohol, Azathioprine, Rantidine and different classof drugs cause acute and chronic liver injury. Keywords: Hepatotoxicity, Hepatotoxicants, Mechanism, Liver injury, Drugs.
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