Anurag Yadav

Abstract

Objective: Study aimed to assess the relation between the ABO blood group and occurrence of COVID-19 and severity. Materials and Methods: This was a single centric retrospective study conducted at the MNR Medical College & Hospital among the patients admitted for COVID-19 infections during the July 25th to 30th October 2020. All the patients who were tested COVID-19 positive and the blood type recorded in the health care record were included in present study. The demographics, comorbidities, and the laboratory data of CBC, RBS, liver function test, renal function test, C-reactive protein, serum ferritin and D-dimmer were reviewed. Result: Total of 365 patients are enrolled in present study (53.2% male and 45.8% female. The blood group of A was common followed with blood group O and group B. 68.5% (n=250) of the patients included had turned to be positive for COVID-19 and 31.5% (n=115) were with negative COVID-19. There was a significant higher odds of the COVID-19 among the blood group A compared to the other blood group type and blood group O had lower odds of the disease. Requirement of ventilator support was significant higher in patients with group A compared to other blood group. In present study, total of 4 patients succumbed to death. Conclusion: There is presence of higher risk of type A blood group compared to other blood group type with susceptibility for the SARS-CoV (COVID-19) and also the severity of the progression of disease. Keywords: SARC­ CoV, COVID­ 19, Mortality, ABO, Blood group.

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Abstract

Background: Coronary heart disease is the leading cause of the death and disability in the developed nations and is increasing rapidly in the developing countries. Study aimed to estimate and compare the small dense LDL-cholesterol (sdLDL-C) in healthy smokers & non-smokers. Materials and Method: This is analytical observational study, conducted at father Muller medical college Mangalore after approval from the institutional Research & Ethics committee. The subjects were selected from the patients coming for the routine health checkups to the hospital. The participants willing to be part of study between the age group of 25-65yrs of age, with history of cigarette smoking were grouped as group II and healthy non-smokers as group I. A 3ml of fasting blood sample was drawn under all precautionary measures and subjected to analysis at central laboratory biochemistry section after separating the serum. Result: Total of 760 normal healthy individuals were included in the current study with 480 healthy cigarette smokers and 280 healthy non-smokers. Lipid profile showed a significant difference between the smokers and non-smokers with elevated LDL cholesterol and the sdLDL cholesterol and reduction in level of HDL cholesterol among the smokers compared to non-smokers. Conclusion: There is a significant higher level of small dense LDL cholesterol among the smokers compared to non-smokers, which can help to predict the risk for future cardiovascular bad events among the smokers.   Keywords: Lipid profile, LDL-cholesterol, Small dense LDL, Cholesterol, Smokers.

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