Lipi B Patel

Abstract

Introduction: Diabetic patients are prone to develop coronary heart disease, stroke and even microvascular complications like diabetic nephropathy, retinopathy and neuropathy. Chronic hyperglycemia is considered an important etiological factor leading to such complications. Diabetic nephropathy is one of the most common causes of chronic kidney disease (CKD) in India. For staging of CKD, estimation of the glomerular filtration rate (GFR) is necessary. One of the commonly used equations to estimate GFR (eGFR) is the equation from the Modification of Diet in Renal Disease (MDRD) study. This study was carried out to assess correlation between glycemic control of type 2 diabetic patients, assessed by HbA1c, with their renal impairment status, checked by eGFR. Materials and Methods: 50 patients of type 2 Diabetes Mellitus (T2DM) and 50 non diabetic controls were enrolled for the study. Their fasting blood sugar (FBS), serum creatinine and HbA1c level were measured and eGFR were calculated using MDRD equation. HbA1c levels were compared with eGFR values. Result: HbA1c levels were significantly correlated with eGFR in diabetic patients. But no significant correlation was found between these two parameters in non diabetic controls. Conclusion: Renal function impairment due to diabetic nephropathy can be predicted by measuring HbA1c levels in diabetic patients and proper measures can be planned to delay significant renal damage. Keywords: eGFR, HbA1c, T2DM.

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