Gerard Joseph Devadassou

Abstract

Prehypertension is associated with excessive morbidity and mortality due to Cardiovascular diseases (CVD). Our study emphasizes the need of early diagnosis of left ventricular diastolic dysfunction in prehypertension patients and to perform echocardiogram in prehypertension middle aged patients. Materials and Methods: Its hospital based cross sectional study done on 50 samples all middle aged patients of both sexes with prehypertension in the age group of 45-64years. Results: The mean E value was found to be 69.78+4.83, mean value of A was 68.88+5.71 and mean value of E/A 1.01+.0.15. About 17(34%) had normal diastolic function E/A Ratio between 1.0-1.5 and 33 (66%) had impaired relaxation grade 1. There is no significant difference between the smokers and non – smokers, likewise for obese and non -obese patients. Conclusion: We conclude that even non obese patients and non- smokers has significant diastolic dysfunction, so prehypertension is risk factor for diastolic dysfunction. Keywords: Prehypertension, Diastolic dysfunction, Echocardiogram, Cardiovascular disease.

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Abstract

Diabetic retinopathy (DR), a kind of micro vascular lesion that is detected on fundus examination, accounts for 40 percent of diabetics over 40 years of age. To determine the correlation of mean platelet volume with diabetic retinopathy. Methodology: Hospital based Case- Control study. 50 patients diagnosed as Type-2 diabetes mellitus with defined diabetic retinopathy. And 50 patients with age and sex matched without the case disease. To all the patients mean platelet volume was done and comparing the significant difference of mean platelet volume between diabetics with retinopathy (cases) and control groups. Results: The mean platelet volume of the diabetic retinopathy and controls were 11.77 + 1.40 and 7.55 + 0.35. Regarding fasting glucose level for diabetic retinopathy and controls were 196.04 + 13.2 and 103.57+12.16 which is significantly higher than the controls (p value + 1.01 which is significantly higher than the control groups 5.48+0.94. (p value Conclusion: Mean platelet volume was reported to be raised in diabetic retinopathy patients compared to the healthy population. Keywords: Diabetic Retinopathy, Mean Platelet Volume, HbA1c, Diabetes Mellitus

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