Vidya Vasudev

Abstract

Introduction: Diseases of thyroid gland are common and have wide spectrum of entities ranging from functional, immune mediated to neoplastic lesions. The aim of this study is to describe the different pattern of lesions in thyroidectomy specimens. Objectives: To study occurrence of various lesions of thyroidectomy specimens. Materials and Methods: This study was done in Dept. of pathology, Mysore Medical College over a period of 2 years from Feb 2017 to Feb 2019. The thyroid diseases were classified on histological grounds into congenital, non- neoplastic and neoplastic lesions that were further sub classified as benign and malignant as per WHO histological classification of thyroid tumors. Results: A total of 104 thyroidectomy specimens were received during this study period. 91 cases (87.5%) were females and 13 cases (12.5%) were males with F: M ratio of 7:1. Non neoplastic lesions accounted for 72% and includes colloid goiter, multinodular goiter, nodular hyperplasia, hashimoto’s thyroiditis, thyroglossal cyst and lymphocytic thyroiditis. Neoplastic lesions accounted for 30% and consists of follicular adenoma as benign neoplasm, 17 malignant cases, 13 cases were of papillary thyroid carcinoma classic type, two cases of follicular carcinoma, one case of well differentiated follicular carcinoma of undetermined malignant potential and one case of non invasive follicular tumor with papillary like nuclear features. Conclusion: Thyroid lesions predominantly affects females. Most commonly seen during 3rddecade of life. Colloid goiter is the commonest non-neoplastic followed by multinodular goiter. Follicular adenoma was the most common benign neoplasm, papillary carcinoma of thyroid was the common thyroid malignancy seen. Keywords: Histopathology, Thyroidectomy specimen.

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Abstract

Introduction: Postmenopausal bleeding is regarded as an omnious and serious alarm of genital pathology. It is a symptom having various etiology and has a strong association with malignancy, which demands its thorough evaluation. Aims and Objectives: The present study was carried out to know the causes of postmenopausal bleeding based on histopathology and the percentage of various benign premalignant & malignant lesions in postmenopausal bleeding. The association with age was also studied. Methodology: This study included 139 specimens received in in Department of Pathology MMC & RI Mysore, with history of postmenopausal bleeding, from January 2013 to December 2014. Results: Mean age of the patients in the study was 57 years. Cervical biopsy was most common biopsy received (43.8%). Benign cases were 51.6%, malignant cases 36.07% and premalignant lesions were 9.27%. Among the benign lesions atrophic endometrium was most common (11.2%). Cervical cancer was most common (33%) among malignancy. Conclusion: Any patient presenting with history of postmenopausal bleeding should be investigated thoroughly to determine the cause of bleeding. Cervical lesions are still the most common cause postmenopausal bleeding so screening programme should be effectively implemented. Keywords: Postmenopausal bleeding, Histopathology.

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