Authors: Ranjita
Objective: To analyse the acute toxicity study and phytochemical screening of phylanthus amarus ethanolic extract on wistar albino rats. Materials and Methods: Acute toxicity study is done on the Wistar albino rats by dividing into 7 groups. Each group consisting of 2 animals [1male & 1 female]. Overnight fasted animals were kept in individual cages and were administered graded dose of Phyllanths amarus ethanol extract. Preliminary phytochemical analysis of the ethanolic extract of the Phyllanthusamarus (PAEE) was done according to standard methods. Results: Evaluation Acute toxicity of Phyllanthusamarus in Wistar albino rats. Results- There was no signs of acute toxicity of any kind like stupor, convulsion, writhing or death after incremental dosing of Phyllanthusamarusethanolic extract (PAEE) to wistar albino rats during close monitoring for initial 2hrs and as well as at the end of 24hrs. Preliminary phytochemical analysis showed positive for Alkaloids, Phytosterols, Saponins, Carbohydrates, Flavanoids and negative for Triterpinoids, Lactones, Tannins, Proteins and Glycosides. Conclusions: Phyllanthus amarus doesn’t seem to have acute toxicity in preliminary animal study. Keywords: Ethanolic extract, Hepatoprotection, Phyllanthus amarus leaves, Wistar albino rat.
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