Jasvir Singh

Abstract

Background: Human b -HCG is a glycoprotein that is expressed in trophoblastic cells and various malignant tumors. Placenta is the known primary trigger of gestational hypertension. Beta HCG is secreted in abundance from placenta. Aims and Objectives: The aim of the present study is to estimate the serum Beta HCG levels in study group consisting of 50 patients (Pregnant Females) of gestational hypertension and in control consisting of same age matched pregnant females. Materials and Methods: The present hospital based observational and analytical study was conducted on 80 patients out of which 50 were diagnosed with gestational hypertension and 30 constituted the control group. The Beta HCG levels were analyzed by Sandwich ELISA Method. Results: The results of the present study showed that there was increase in Beta HCG levels in the gestational hypertensive patients with a mean value of Beta HCG was 117.79 ± 57.7mIU/ml, mean value of Systolic blood pressure was 127.3 +13.9 mm of Hg and mean value of Diastolic blood pressure was 78.6 +16.1 mm of Hg which were statistically significant (p= Conclusion: Serum Beta HCG levels were elevated in gestational hypertension, when compared with controls. Due to trophoblast response to hypoxia there exists an abnormal secretory function of the placenta in cases of gestational hypertension which leads to development of a hypersecretory state which is seen as a rise in Beta HCG levels. This study showed that estimating serum Beta HCG levels is a useful indicator to identify women who are likely to develop gestational hypertension in the same pregnancy. Keywords: SBP(Systolic Blood Pressure), DBP(Diastolic Blood Pressure), b -HCG (Beta Human Chorionic Gonadotrophin), GHT(Gestational Hypertension), IUGR(Intra Uterine Growth Restriction), LBW (Low Body Weight) ELISA (Enzyme Linked Immuno Sorbent Assay).

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