Vatturi Saumya

Abstract

The study aims to compare the serum zinc and copper levels in chronic hepatitis B and HBV induced cirrhosis, and whether these parameters can be used as markers of conversion from chronic hepatitis to cirrhosis, and if their supplementation would delay the course of the disease. 50 chronic hepatitis B and 80 HBV induced Cirrhosis patients were included in the study. Serum zinc and copper levels were estimated in 1800 UV spectrophotometer. Statistically significant decrease in serum zinc levels and a statistically significant increase in serum copper levels were observed in cirrhosis when compared to chronic hepatitis B (P serum zinc and increased serum copper levels indicate the conversion of chronic hepatitis B to cirrhosis. Supplementation of zinc and reduction of copper intake will delay the progression of chronic hepatitis B to cirrhosis and improve survival. Keywords: Chronic hepatitis B, Cirrhosis, Zinc, Copper.

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Abstract

Objective: To evaluate the usefulness of fasting plasma glucose, lipid profile, and thyroid-stimulating hormone (TSH) estimated at first trimester in predicting gestational diabetes mellitus. Materials and Methods: A prospective study was done. Samples were collected after 12 hours of fasting from 250 women within the gestational age of 12 weeks and were analyzed for plasma glucose, lipid profile, and TSH in the fully automated analyzers EM 200 and Cobas e411 by enzymatic and electro chemiluminescence immunoassay respectively. Oral glucose tolerance test (OGTT) with 75 gm was performed in these subjects at 24 -28 weeks of gestational age. Data was analyzed using SPSS 19.0. To analyze statistically significant differences in means of continuous variables between 2 groups, a student t-test was used. Multiple logistic regression analyses were performed to find the presence of association of these independent variables with GDM. Results: Out of 250 pregnant women, 51 (25%) developed GDM, 149(75%) had normal glucose tolerance. GDM was found to have an association with fasting plasma glucose with (OR 2.846,1.506- 5.362, P

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