Amit S Kamdi

Abstract

Background: The various antianxiety drugs currently used cause numerous adverse drug reactions. Though in the late seventies some work was done on Withania coagulans, it is the vulnerable species not found plentiful. Therefore, it was worthy to investigate the anxiolytic actions of alcoholic extract of Withania coagulans fruits in Swiss albino mice by using Elevated Plus Maze (EPM) test. Aim: To study the antianxiety activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by Elevated Plus Maze (EPM) test. Materials and Methods: The antianxiety activity was measured using Elevated Plus Maze (EPM) test. The antianxiety drugs promote the mice to spend more time in open arm and less time in close arm. This increase in the time spent in the open space as well as number of entries from close to open space was correlated statistically with control and standard in the EPM test. Statistical Analysis: One way ANOVA was used for the statistical analysis. Results: Time spent in the open arm (Open) as well as number of entries into the open arm (EOA) by the Swiss albino mice was statistically highly significantly (p-value < 0> extract of Withania coagulans fruits in Elevated Plus Maze (EPM) test. Conclusion: The alcoholic extract ofWithania coagulans fruits established the antianxiety activity in Swiss albino mice by Elevated Plus Maze (EPM) test. Keywords: Antianxiety, Elevated Plus Maze (EPM), Swiss albino mice (SAM), Withania coagulans.

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Abstract

Background: People spend about one third of their life in sleeping. The various sedative and hypnotic drugs currently used have various adverse drug reactions. In 1977 Budhiraja et al have done insufficient work on the Withania coagulans – a susceptible species that is not found plentiful in the world. Therefore, it was critical to discover the Central Nervous System &#40;CNS&#41; depressant activities of alcoholic extract of Withania coagulans fruits in Swiss albino mice by means of actophotometer. Materials and Methods: The spontaneous locomotor action was assessed by means of the actophotometer. The CNS depressant medications reduce the exploratory action in rodent as they weaken the motor coordination so that rodent is stationary for a considerable time. Thus, there is fewer interruptions to the rays of light. This spontaneous locomotor movement duration is statistically compared with the control, standard and the test drugs. Results: There was statistically highly significant (p-value < 0> alcoholic excerpt of Withania coagulans fruits with spontaneous locomotor action in Swiss albino mice on the photoactometer. Conclusion: The alcoholic excerpt of Withania coagulans fruits established the CNS depressant action in Swiss albino mice by photoactometer. Keywords: CNS depressant; Photoactometer; Swiss albino mice (SAM); Withania coagulans.

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Abstract

Background: The central nervous system &#40;CNS&#41; depressant effect is caused by the numerous sedative and hypnotic drugs that are currently used. Though in the late seventies some work was done on Withania coagulans, it is the vulnerable species not widely scattered. Therefore, it was worthy to investigate the CNS depressant activities of alcoholic extract of Withania coagulans fruits in Swiss albino mice by using rota rod test. Aim: To study the motor coordination activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by Rota Rod Test. Materials and Methods: Motor coordination was measured by using the Rota Rod Test. The CNS depressant drugs reduce the endurance time of mice on the rotating rod as they weaken the motor coordination so that mice fall early on the revolving rod. This endurance time is tested statistically among the control, standard and the test drugs. Statistical Analysis: One way ANOVA was used for the statistical analysis. Results: The endurance time in Swiss albino mice was statistically highly significantly (p-value < 0> associated with the alcoholic extract of Withania coagulans fruits on rota rod test. Conclusion: The alcoholic extract of Withania coagulans fruits established the CNS depressant activity in Swiss albino mice by rota rod test. Keywords: CNS depressant, Rota rod test, Swiss albino mice (SAM), Withania coagulans.

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