Sindhu S

Abstract

Background: Tracheal extubation process evokes stress response which causes autonomic variations such as tachycardia, rise in systolic arterial blood pressure and diastolic arterial blood pressure which is potentially lethal in high risk patients. Thus this study is conducted to compare the efficacy between 0.15mg/kg and 0.25mg/kg of iv Labetalol in the suppression of haemodynamic response to Extubation. Materials and Methods: 60 participants aged between 18-55 yrs belonging to ASA 1 or 2 were randomly allocated into 2 groups. Group Lb received injection Labetalol 0.15mg/kg and Group Lt received injection Labetalol 0.25mg/kg. Heart rate, systolic arterial blood pressure and diastolic arterial blood pressure were recorded at basal, two, five, eight minutes after drug infusion, at extubation and one, three, five, eight, ten and fifteen minutes post extubation. Results: Group Lt showed a better lowering values in heart rate, systolic arterial blood pressure and diastolic arterial blood pressure after drug infusion, at Extubation, and fifteen minutes post Extubation compared to Group Lb. Conclusion: Injection Labetalol 0.25mg/kg showed a effective suppression of haemodynamic response to Extubation compared to injection Labetalol 0.15mg/kg. Keywords: Labetalol. Haemodynamic response, Extubation.

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Abstract

Background: General anaesthesia with endotracheal intubation is the definite way of securement of airway. Tracheal extubation is associated with increased sympathoadrenal response which leads to deleterious consequences in susceptible patients. This study aims to evaluate the efficacy of dexmedetomidine 0.6mcg/kg iv in the suppression of sympathoadrenal response to tracheal extubation. Materials and Methods: Sixty participants aged between 18-55yrs belonging to ASA 1 or 2 were randomly allocated into 2 groups. Group Dxd received injection Dexmedetomidine 0.6mcg/kg iv and Group Cl received normal saline. Heart rate, systolic and diastolic blood pressure were recorded at baseline, 2, 5, 8 minutes after drug infusion, at extubation and 1,3,5,8,10 and 15 minutes post extubation. Results: Group Dxd showed lower heart rate, systolic and diastolic blood pressure at extubation, and till 15minutes postextubation compared to Group Cl. Conclusion: Dexmedetomidine 0.6mcg/kg iv effectively attenuates the sympathoadrenal response to tracheal extubation. Keywords: Dexmedetomidine, Extubation, Sympathadrenal response.

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Abstract

Background: Tracheal extubation evokes various degrees of disturbances in the autonomic nervous system in the form of tachycardia, hypertension which can cause deleterious consequences in susceptible patients. Hence this study was conducted between iv Dexmedetomidine and iv Labetalol to compare their effectiveness in the suppression of haemodynamic response to tracheal extubation. Materials and Methods: 60 participants aged between 18-55 yrs belonging to ASA 1 or 2 were randomly allocated into 2 groups. Group Dd received injection Dexmedetomidine 0.6mcg/kg iv and Group Ll received injection Labetalol 0.25mg/kg body weight. Heart rate, systolic and diastolic blood pressure were recorded at baseline, 2,5,8 minutes after drug infusion, at extubation and 1,3,5,8,10 and 15 minutes post extubation. Results: Group Dd showed a better decrease in heart rate, systolic and diastolic blood pressure at extubation, and 15 minutes post extubation compared to Group Ll. Conclusion: Injection Dexmedetomidine 0.6mg/kg showed a better attenuation of sympathoadrenal response to extubation compared to injection Labetalol 0.25mg/kg. Keywords: Dexmedetomidine, Labetalol, Extubation.

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