Pallav Jain

Abstract

Autosomal recessive inheritance pattern in a case of hereditary optic atrophy is uncommon. Patients with recessive optic atrophy without involvement of any other system are rare. There is no causative gene or genetic mutation associated with it. Here we report a case of a 16-year-old girl which was diagnosed to be a case of AROA. Genetic analysis done in this patient revealed G15043A mutation. Identification of similar cases of the AROA can increase our understanding of the disorder and formulate treatment options. Keywords: Autosomal recessive optic atrophy, Hereditary optic atrophy, G15043A mutation.

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Abstract

Context: During hospitalization due to stroke, patients can have acute kidney injury (AKI) as a possible complication which is frequently overlooked and underestimated in clinical trials. Aims: To assess the prevalence of renal dysfunction in acute stroke patients and to assess its prognostic significance Design, Methods and Materials: A total of 100 patients were recruited for this study with diagnosis of stroke. Renal dysfunction was evaluated in the form of Acute kidney injury and unrecognized renal dysfunction (Baseline Normal serum Creatnine Statistical analysis: Analysis of data was done using SPSS-17.Independent t-test and chi-square test were used to calculate difference between two groups Results: Our study shows prevalence of acute kidney injury in patients of stroke is 15%. Moreover, the study showed that AKI after stroke was associated with higher in-hospital mortality and poorer functional outcome at 1 month. Conclusions: Acute kidney injury appears to be a common complication after stroke and is related to increased mortality and disability in stroke. Key Messages: AKI is common complication after stroke and frequent cause of poor functional outcome. Keywords: Acute kidney injury, Stroke, Renal function.

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