Noreen Munshi

Abstract

 "The wolf isotopic phenomenon corresponds to the appearance of a skin disease in a place on the body that was previously affected by another, already healed dermatosis." A 35-year-old woman presented with a transversely distributed zosteriform eruption about 12 to 14 cm in length, consisting of erythematous, scaly, moderately pruritic papules on the left flank that spread to the back (does not cross the midline) for several weeks after locally healed herpes zoster (HZ) lesions. No other skin or mucosal sites were included. Routine examination of blood, urine and stool showed no abnormality. A biopsy sample was taken from one of the lesions. Histopathological examination showed typical lichen planus changes, confirming the diagnosis of post-Herpes zoster zosteriform lichen planus (ZLP). The lesions resolved after treatment with topical steroids. Zosteriform lichen planus (ZLP) is an example of a Wolf isotopic phenomenon appearing after HZ at the same site. The exact pathogenesis of ZLP is unknown, it is assumed that persistent viral proteins could be responsible for the hypersensitivity reaction.   Keywords: Herpes zoster, Zosteriform lichen planus

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Abstract

Background: The majority of treatments for skin warts include destructive techniques like electrocautery and cryotherapy. These techniques of treatment frequently result in recurrence and scarring. Examining the safety and efficiency of intralesional vitamin D3 injection in cutaneous warts is the goal of this study. Materials and Methods: Total 50 people with recalcitrant warts of different dimensions, frequencies, and longevity participated in the study. 0.2 to 0.5 ml of vitamin D3 (600,000 IU, 15 mg/ml) were injected into the bases of warts. A maximum of 5 warts were administered per session, with sessions occurring every 2 weeks till the warts vanished, or for a total of 3 sessions. Following the final injection, individuals were monitored for six months to look for any recurrence. Results: The trial was completed by 50 patients. Out of 50 patients, 35 (or 70%) showed a complete reaction, five (10%) showed a partial response, and ten (10%) showed no response. In every case, the distant warts completely disappeared. Conclusion: A safe, effective, and affordable therapy option for resistant warts is intralesional vitamin D3.   Keywords: Vitamin D3, Intralesional treatment, Cutaneous warts

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Abstract

Mastocytosis is a rare, acquired multisystem disorder of increased number of mast cell in the skin and other tissues. Mastocytosis is caused by several activating mutations in the KIT gene.1 Although mastocytosis is primarily a systemic disorder, it often presents with skin lesions to dermatologists. Urticaria Pigmentosa is the most common pattern of cutaneous mastocytosis in adults and children. Keywords: Urticaria Pigmentosa, Mastocytosis.

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