Atanu Kumar Ba

Abstract

Background: In the present situation globally, there is an increasing burden of diabetes mellitus in the developing and developed countries alike. With an increase in the carbohydrates intake due to the consumption of junk and unhealthy food, the cases of diabetes mellitus are alarmingly increasing. Diabetes is not a single disease in itself. It has been estimated that nearly 59.2 million patients around the world suffer from diabetes mellitus. Aim: To assess the role and significance of haematological parameters in diabetes in Southern Odisha  Materials and Methods: It was a prospective study carried out at the Department of Pathology at the  MKCG Medical College Berhampur, Ganjam (Odisha). The study period was from March 2019 to August 2019. One hundred subjects were registered for the study, among which 50 of the patients were in the diabetic group, and the remaining 50 were in the non-diabetic group (Group 1). The diabetics were further divided into two groups diabetics with HbA1c 7 with 25 patients (Group 3). There are chances that patients with very low haemoglobin may show erroneous HbA1c values. Thus, to overcome this, we measure HbA1c of every patiente twice using Sebia Capillary Flex-Piercing instrument to acertain the accuracy and reliability of the study. The biological reference range in both males and females for RBC count is 3.8-6.5 million/cu.mm, Hb is 11.5-17mg/ dl, Hematocrit is 37-54%, MCV is 80-100m3 , MCH IS 27-32 pg, MCHC is 32-36g/dl and RDW is 11-16%. All the patients who had hypo/hyperthyroidism, CKD, an inflammatory disorder, and congenital heart disease were excluded from the study. Result: Most of the patients were aged between 41-60 years in group 1, group 2, and group 3. It was also evident from the above table that the number of female patients was more as compared to the number of males. Among different values of red blood cell parameters in group 1 and group 2, there was a statistically significant difference between the two groups with respect to RBC. Also, there was a statistically significant difference between the group 1 and group 3 with respect to Hb values. Conclusion: In light of the above results, it was evident that the poor control diabetic subjects face more complex diseases along with anaemia. Therefore, it is required that the patients must undertake regular haemoglobin level tests so that the glycemic index is under control. Keywords: Hb, Diabetes Mellitus, Red Blood Cells.

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Abstract

Background: Rated among the most common disease worldwide, Hypertension is fast becoming a cause of significant morbidity and mortality. Owing to its widespread it has become one of the most common risk factors of serious disease including cardiovascular diseases (CVD) along with other illness like renal malfunctioning, myocardial infraction and even leads to loss of vision. There are various other biomarkers of the hypertensive patients that help in realizing the real threat of the cardiovascular diseases among those who are suffering from hypertension. The discrepancies in the different lipid profile biomarkers like total cholesterol (TC), low-density lipoproteins (LDL), serum levels of triglycerides (TG) pose a great risk for the development of CVDs. Aim: To assess the lipid profile of the hypertensive patients in Southern Odisha. Materials and Methods: It was n observational study undertaken at MKCG Medical CollegeBerhampur, Ganjam (Odisha). One hundred fifty patients were included in the study belonging to both the genders. The duration of the study was from June 2019 to November 2019. The patients were divided into two groups, group 1 with 70 patients who were non-hypertensive and 80 patients in group 2 who were hypertensive. CHOD-PAP was the method used to measure the serum total cholesterol. The GPO-Triender method was used to assess the triglycerides. Results: Sixty per cent of the patients in the non-hypertensive group were males, and 70% of the patients in the hypertensive groups were males. The SBP for the non-hypertensive patients was 1204.12 while the DBP was 80.13.21. On the other hand, the SBP for the hypertensive group was 1699.10, and the SBP was 96.125.06. The mean total cholesterol for the non-hypertensive group was 164.253.99, mean Triglycerides was 129.9 8.3, mean HDL was 47.26 5.54, mean LDL was 93.76 12.06, and mean VLDL was 26.98 2.67. On the flip side, the mean total cholesterol for the hypertensive group was 168.9 6.27; mean Triglycerides was 181.57 31.9, mean HDL was 41.96 2.65, mean LDL was 179.6 20.08, and mean VLDL was 37.54 5.60. Conclusion: In light of the above results, it was identified that dyslipidemia was found to be closely associated with hypertension. It was also concluded that an increase in the blood pressure would result in disturbing the lipoprotein metabolism. Keywords: SBP, DBP, Hypertension, Lipid Profile.

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