Suman Singh

Abstract

Juvenile xanthogranuloma(JXG) is an uncommon benign histiocytic cutaneous lesion which is seen primarily in first two decades of life. There is not much literature available on its cytology. We present a case of solitary juvenile xanthogranuloma in a 43 years old female located above left nasal ala which was diagnosed on Fine needle aspiration cytology and subsequently confirmed on histology. Characteristic cytological features favored a diagnosis of juvenile xanthogranuloma. Keywords: Juvenile Xanthogranuloma, Cytology, Adult.

View Article

Abstract

Context: Fineneedle aspiration cytology (FNAC) is an important tool in the diagnosis of soft tissue tumours. The method is widely tested in recent years as it is easy, quick, safe and fast compared to histopathology. Aims: Present study is being conducted to study the cytomorphological patterns of soft tissue tumours and find out the efficacy of FNACwhen compared with histopathology aided with immunostains. Settings and Design: Fifty six cases presented with soft tissue swellings were subjected to FNAC. The results were compared with histopathology aided with immunohistochemistry. Materials and Methods: Present study was a prospective study conducted between July 2007 and December 2008 for a period of one and a half year in the department of Pathology of a tertiary care institute. Patients who presented with soft tissue tumours were included in the study. Patients with inflammatory swellings and those in which histopathology was not available were excluded. Fifty six cases presented with soft tissue swelling were subjected to fine needle aspiration (FNA). Findings were compared with histopathology. Immunohistochemistry was used in some cases for exact diagnosis.| Statistical analysis used: sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy. Results: In the primary diagnosis of soft tissue tumours by FNAC, the study showed sensitivity and specificity of 93.75% and 94.4% for malignancy. Overall diagnostic accuracy was 94.4% for both benign and malignant neoplasms. Positive predictive value and negative predictive value was 88.24% and 97.3% for malignancy. Conclusions: FNA of soft tissue tumours yields specific architechtectural patterns and cytological details. FNAC helps in the initial management of soft tissue tumours as it is rapid and fairly accurate. Keywords: Soft issue tumours, Cytology, Patterns, Histopathology.

View Article

Abstract

Introduction: Being the most common benign tumor of the breast, fibroadenoma show considerable histologic changes. It is important to highlight them as some of the changes are associated with increased risk of breast cancer. Aims and Objectives: To study the pattern and histologic changes in fibroadenoma breast. Materials and Methods: Retrospective analysis of histopathology of 55 cases of fibroadenoma breast diagnosed between Jan 2017 to Jun 2018. The pattern, epithelial and stromal changes were examined. Result: Commonest age group involved was in 3rd decade. Pericanalicular pattern was the predominant pattern. Apocrine and cystic change was the commonest change in epithelium. Two cases (3.6%) showed features of complex fibroadenoma. Three (5.5%) cases showed foci of tubular adenoma. Epithelial hyperplasia was seen in 5(9%) of cases of which 2 were mild, 2 were moderate and one was atypical hyperplasia. Inflammatory infiltrate in stroma was frequently observed. Conclusion: Fibroadenoma showed variety of histological changes of which complex fibroadenoma and epithelial hyperplasia are significantly important which requires appropriate management and follow up. Keywords: Fibroadenoma, Pattern, Histology, Changes.

View Article