Akshay Jain Salecha

Abstract

Background: Psoriasis is an immune-arbitrated cutaneous disorder in which both genetic and habitational factors play a decisive role. Certain endocrinological disturbances like thyroid dysfunction can exacerbate the disease. This research aspires in knowing the prevalence of thyroid disease in psoriatic patients and the severity of psoriasis in those with thyroid disease with age and gender-evened controls. Materials and Methods: This was a case-referent study encompassing 100 adult psoriasis patients and 100 age and gender-evened healthy controls. The statistical differences between proportions were determined by chi-square analysis. A P-value of Results: In the current study, thyroid dysfunction was present in 20 % of cases and 8% of controls and serum TSH levels were significant among cases, with a p-value of 0.046. There was a clear association betwixt the psoriasis area severity index (PASI) and presence of thyroid dysfunction with a significant P-value of < 0> Conclusion: Observations from our study provide compelling evidence that psoriasis is associated with thyroid dysfunction, which may affect the quality of life, as we documented higher PASI scores in psoriatics with thyroid dysfunction than those with normal thyroid function. It also highlights the importance of adopting a multidimensional approach for the management of psoriasis.   Keywords: Hyperthyroidism, Hypothyroidism, Psoriasis, Thyroid dysfunction

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Abstract

Background: Vitiligo is an usual acquired pigmentary disorder of the skin characterized by well-circumscribed depigmented macules and patches. Though the association between vitiligo and thyroid disorders has been suggested, only a few studies from India and overseas have paid attention to describe the association between vitiligo and thyroid abnormalities, particularly in children. Hence, this study was taken up for evaluating thyroid disease in childhood vitiligo compared to controls in a tertiary care centre. Materials and Methods: This was a hospital-based case-control study conducted at a tertiary teaching hospital over 18 months which included 50 new patients of vitiligo and 50 age and sex-matched controls. Blood samples were garnered from cases and controls to access the levels of free triiodothyronine (fT3), free thyroxine (fT4), Thyroid-stimulating hormone ( TSH), anti-thyroid peroxidase (anti-TPO), and anti-thyroglobulin (anti –Tg). Results: In our study, females outnumbered males in both groups. The frequencies of thyroid function and thyroid autoantibody abnormalities among vitiligo patients and control were 32% and 6%, respectively. The difference between case and controls for thyroid function abnormality was significant with a p-value of 0.001. Conclusion: Our study found a significant association betwixt thyroid disease and childhood vitiligo. Thus, evaluating vitiligo patients for thyroid abnormalities help to detect thyroid diseases or determine the possibility of eventual onset.   Keywords: Childhood vitiligo, Thyroid, Autoantibody

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