Sankha Bhattacharya

Abstract

Dendrimers holds potential in abating restrictions of other available treatments through the development of functionalized particles for targeted treatment. By developing functionalized particles for targeted treatment, dendrimers have the ability to reduce the limitations of other available therapies. Dendrimers have many advantages over other nanoparticles, making them perfect candidates for more efficient and targeted drug delivery. Dendrimers have the ability to deliver vast quantities of drugs to particular locations. They can also be used to monitor the progress of the procedure, giving them a theranostic capability that has never been seen before. Dendrimers show their potential applicability for effective cancer treatment for the near future. These article highlights the evolution timeline of dendrimers and various related aspects of the past four decades. These also involve the basic structure and information of dendrimers along with the current and future perspective. As a result, it is important to study dendrimers in order to keep up with recent developments. Keywords: Dendrimers, PAMAM dendrimer, Theranostic agents, Polyphenylene dendrimers, Encapsulation, Drug delivery system

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Abstract

Mucormycosis is a life-threatening fungal infection caused by a group of moulds known as mucormycetes. It is a viral disease, increasingly progressive, rapidly triggers in diabetic, immunocompromised and trauma patients. Diabetic patients seem to have the classic rhinocerebral variant. Rhinocerebral mucormycosis begins as a nasal cavity, paranasal sinus, and orbital soft tissue infection. In immunocompetent patients, direct injection also induces cutaneous form. Cutaneous mucormycosis occurs in soft tissue and may infect underlying tissues. Mucormycosis is more frequent in people with major underlying disorders such as diabetic acidosis or acute leukaemia and those taking corticosteroids or cytotoxic drugs. This disease occurs in patients by inhaling fungus spores. Mucormycosis occurs in clinical manifestations. Disseminated mucormycosis is a rare form of mucormycosis, affecting individuals with compromised immune systems. The disease travels to other areas of the body, thereby being prevalent. Brain, core, spleen, eyes, and other organs are among the organs that may be affected. Mucormycosis is a dangerous infection that requires antifungal drugs such as amphotericin B, posaconazole, or isavuconazole. This compilation addresses conceptual background on medicines used to treat mucormycosis, especially in India. Keywords: Mucormycosis, Amphotericin B, Diabetic acidosis, COVID-19.

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